A qualitative exploration of consumers’ perceived impacts, behavioural reactions, and future reflections of the EU Tobacco Products Directive (2017) as applied to electronic cigarettes

Background: Electronic cigarette regulations included in the Tobacco Products Directive (TPD), Article 20, implemented in Europe by May 2017, aimed to improve safety for e-cigarette consumers, and prevent uptake among non-smokers, particularly young people. Before implementation, there were significant concerns from consumers, industry, and some in the scientific community about the potential negative impact of the TPD on people using e-cigarettes to stay stopped from smoking. To date, there is limited evidence on how the TPD has affected consumers. This study aimed to add insight into how consumers perceived and experienced the regulations. Methods: Qualitative data, collected between March 2018 and March 2019, relating to participant views of the TPD were extracted from 160 interviews/extended surveys of e-cigarette consumers as part of a wider study into e-cigarette use trajectories (ECtra study). Data were thematically analysed. Results: Awareness of the TPD amongst consumers was not universal. Participants’ smoking behaviour did not appear to be influenced by the legislation. Participants were reassured by manufacturing regulations and requirements for ingredients labels. Participants responded negatively to changes perceived to cause inconvenience and extra plastic waste. The product restrictions prompted some participants to purchase non-compliant products illegally, potentially putting their safety at risk. Conclusions: E-cigarette regulation should focus on ensuring product safety. Raising awareness of the TPD amongst consumers and smokers could be beneficial

Pottery from Zakro

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Analysis of USAF Medium and Heavylift Space Launch Mission Reliability Requirements

The launch services that the USAF procures to carry DOD payloads into orbit are characterized by high risks and high costs. If a launch vehicle experiences a catastrophic failure, the cost of the entire launch vehicle, the launch processing, and the payload are completely lost (often in excess of 1,5 billion dollars.) Despite this enormous risk for the payload customer, and indeed the launch provider, launch success rates around the world are not much above 90 percent. The current USAF medium and heavylift launch systems are often based on technology that is 20 years old and older. Furthermore, little historical data exists because of the complex technologies used and the unique nature of individual missions. As such, reliability management is limited and faces serious shortcomings. This research investigates the various shortcomings associated with mission reliability measurement and management. Through literature review, case study analyses and interviews, the shortcomings are determined and analyzed. The results of this thesis effort demonstrate these shortcomings. Recommendations are presented for immediate improvement to selected shortcomings and suggestions are made for future research

On the necessity of complexity

Wolfram's Principle of Computational Equivalence (PCE) implies that universal complexity abounds in nature. This paper comprises three sections. In the first section we consider the question why there are so many universal phenomena around. So, in a sense, we week a driving force behind the PCE if any. We postulate a principle GNS that we call the Generalized Natural Selection Principle that together with the Church-Turing Thesis is seen to be equivalent to a weak version of PCE. In the second section we ask the question why we do not observe any phenomena that are complex but not-universal. We choose a cognitive setting to embark on this question and make some analogies with formal logic. In the third and final section we report on a case study where we see rich structures arise everywhere.Comment: 17 pages, 3 figure

ALTRUISM VIA KIN-SELECTION STRATEGIES THAT RELY ON ARBITRARY TAGS WITH WHICH THEY COEVOLVE

Hamilton's rule explains when natural selection will favor altruism between conspecifics, given their degree of relatedness. In practice, indicators of relatedness (such as scent) coevolve with strategies based on these indicators, a fact not included in previous theories of kin recognition. Using a combination of simulation modeling and mathematical extension of Hamilton's rule, we demonstrate how altruism can emerge and be sustained in a coevolutionary setting where relatedness depends on an individual's social environment and varies from one locus to another. The results support a very general expectation of widespread, and not necessarily weak, conditional altruism in nature.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72180/1/j.0014-3820.2004.tb00465.x.pd

Multi-agent system for dynamic manufacturing system optimization

This paper deals with the application of multi-agent system concept for optimization of dynamic uncertain process. These problems are known to have a computationally demanding objective function, which could turn to be infeasible when large problems are considered. Therefore, fast approximations to the objective function are required. This paper employs bundle of intelligent systems algorithms tied together in a multi-agent system. In order to demonstrate the system, a metal reheat furnace scheduling problem is adopted for highly demanded optimization problem. The proposed multi-agent approach has been evaluated for different settings of the reheat furnace scheduling problem. Particle Swarm Optimization, Genetic Algorithm with different classic and advanced versions: GA with chromosome differentiation, Age GA, and Sexual GA, and finally a Mimetic GA, which is based on combining the GA as a global optimizer and the PSO as a local optimizer. Experimentation has been performed to validate the multi-agent system on the reheat furnace scheduling problem

A Memetic Analysis of a Phrase by Beethoven: Calvinian Perspectives on Similarity and Lexicon-Abstraction

This article discusses some general issues arising from the study of similarity in music, both human-conducted and computer-aided, and then progresses to a consideration of similarity relationships between patterns in a phrase by Beethoven, from the first movement of the Piano Sonata in A flat major op. 110 (1821), and various potential memetic precursors. This analysis is followed by a consideration of how the kinds of similarity identified in the Beethoven phrase might be understood in psychological/conceptual and then neurobiological terms, the latter by means of William Calvin’s Hexagonal Cloning Theory. This theory offers a mechanism for the operation of David Cope’s concept of the lexicon, conceived here as a museme allele-class. I conclude by attempting to correlate and map the various spaces within which memetic replication occurs

The unique contribution of e-cigarettes for tobacco harm reduction in supporting smoking relapse prevention

Background: We have little understanding of how vapers use e-cigarettes beyond cessation. E-cigarettes may have a role to play in reducing the health-related harms of tobacco smoking, through not only assisting smoking cessation attempts but also supporting long-term abstinence from smoking. However, there are fears that vaping may lead to the ‘renormalisation’ of smoking type behaviours. This study aimed to explore patterns of use and reported experiences of vapers quitting smoking using an e-cigarette in relation to long-term smoking status (abstinence or relapse). Methods: A purposive sample of 40 UK vapers was matched to a sampling frame of demographic characteristics from a representative sample of UK quitters. Following full informed consent, semi-structured qualitative interviews were conducted. Data were thematically analysed by two members of the research team. Final thematic analysis was verified and agreed by consensus. Results: The sample self-reported long histories of tobacco use and multiple previous quit attempts which had eventually resulted in relapse back to smoking, although a small but important group had never before attempted to quit. Initiating e-cigarette use was experienced as a revelation for some, who were quickly able to fully switch to using e-cigarettes as an alternative to tobacco smoking. For others, periods of dual use or smoking relapse combined with attempts at vaping that were not initially satisfactory. Many of these chose a cheaper ‘cig-a-like’ device which they found to be inadequate. Experimentation with different devices and different setups, over time, resulted in some ‘sliding’ rather than switching to vaping. This involved periods of ‘dual use’. Some settled on patterns of vaping as a direct substitute of previous tobacco smoking, whereas others reported ‘grazing’ patterns of vaping throughout the day that were perceived to support tobacco smoking abstinence. Conclusions: Our data demonstrates that e-cigarettes may be a unique harm reduction innovation for smoking relapse prevention. E-cigarettes meet the needs of some ex-smokers by substituting physical, psychological, social, cultural and identity-related aspects of tobacco addiction. Some vapers reported that they found vaping pleasurable and enjoyable—being more than a substitute but actually preferred, over time, to tobacco smoking. This clearly suggests that vaping is a viable long-term substitute for smoking, with substantial implications for tobacco harm reduction

Evolution of virulence: triggering host inflammation allows invading pathogens to exclude competitors.

Virulence is generally considered to benefit parasites by enhancing resource-transfer from host to pathogen. Here, we offer an alternative framework where virulent immune-provoking behaviours and enhanced immune resistance are joint tactics of invading pathogens to eliminate resident competitors (transferring resources from resident to invading pathogen). The pathogen wins by creating a novel immunological challenge to which it is already adapted. We analyse a general ecological model of 'proactive invasion' where invaders not adapted to a local environment can succeed by changing it to one where they are better adapted than residents. However, the two-trait nature of the 'proactive' strategy (provocation of, and adaptation to environmental change) presents an evolutionary conundrum, as neither trait alone is favoured in a homogenous host population. We show that this conundrum can be resolved by allowing for host heterogeneity. We relate our model to emerging empirical findings on immunological mediation of parasite competition